A name on the label
is a starting point.

Cyspera Intensive now lists 7% cysteamine, while a reviewed melasma trial used 5%. Different strengths and comparators cannot be treated as finished-product evidence for the current formula.

An ingredient used in selected pigment treatments. In the US, hydroquinone skin-lightening products are not approved for over-the-counter sale. Ask about the exact prescription and intended treatment period.

An ingredient mentioned in dermatology guidance and used in some pigment formulas. Its presence is not evidence that every combination performs the same way, or that naturally derived means irritation-free.

Included in Spot On’s advertised combination. A named supporting ingredient does not establish the finished cream’s tolerability, concentrations, or effectiveness for a specific condition.

One option discussed in melasma guidance and in some personalized prescriptions. A cosmetic product and a prescribed preparation should not be treated as identical because they share this name.

A topical serum and an oral prescription are different products and routes. Read the exact formula and evidence. Our Naturium review also identifies conflicting concentration wording on the manufacturer’s pages.

AAD guidance discusses tinted sunscreen containing iron oxide for melasma. Protection from visible light can matter alongside UV protection; it does not replace an assessment of a changing spot.